One Portland Street, formerly known as 610 Main Street South, is fully occupied by Pfizer Pharmaceuticals, Inc., a breakthrough leader in the fight against Alzheimer’s disease, diabetes, and other major illnesses. Just steps away from several MIT biomedical labs conducting research relevant to Pfizer’s interests, this multidisciplinary research facility is positioned to facilitate innovative MIT-Pfizer collaborations. At this location, Pfizer will conduct ground-breaking research and development anchored by its Neuroscience Research Unit and the Cardiovascular, Metabolic, and Endocrine Diseases (CVMED) unit.

The multidisciplinary lab enhances the growing life-science cluster in the Osborn Triangle – home to Novartis and the Lab|Central innovation hub as well as Pfizer – and the Kendall Square area. Inside, the collaborative culture of Kendall Square is reflected in One Portland’s design, where dynamic communal workspaces enable more than 1,000 Pfizer employees to innovate and solve problems together.

Together, One Portland and the building at 610 Main Street form a complex with 500,000 square feet of state-of-the-art space, including offices, laboratories, an underground garage, and 10,000 square feet of retail along Main Street.